Get evolutionary parameters from the model

Usage

get_mutation_rates(object, ...)

# S3 method for cevodata
get_mutation_rates(object, models_name = "powerlaw_fixed", ...)

# S3 method for tbl_df
get_mutation_rates(object, ...)

get_selection_coefficients(object, ...)

# S3 method for cevodata
get_selection_coefficients(
  object,
  models_name = "powerlaw_fixed_subclones",
  Nmax = 10^10,
  ...
)

# S3 method for tbl_df
get_selection_coefficients(object, Nmax = 10^10, ...)

Arguments

object

cevodata object or models tibble

...

other arguments

models_name

models_name

Nmax

Time when tumour is sampled (in tumour doublings)

Functions

• get_mutation_rates(): Get mutation rates by Williams Use ...

• get_mutation_rates(cevodata): Get mutation rates by Williams

• get_mutation_rates(tbl_df): Get mutation rates by Williams

• get_selection_coefficients(): Get subclonal selection coefficients Williams

  Use properties of subclone fit to calculate selection intensity, selection is defined as the relative growth rates of host tumour cell populations ($\lambda h$) vs subclone ($\lambda s$): $$1+s=\lambda h / \lambda s$$

• get_selection_coefficients(cevodata): Get subclonal selection coefficients Williams

• get_selection_coefficients(tbl_df): Get subclonal selection coefficients Williams